David Hsu joined the IGSP in 2009 and also serves as an Assistant Professor in the Department of Medicine. Dr. Hsu received his MD, PhD degree at the University of North Carolina, Chapel Hill. He completed an Internal Medicine Residency at the University of Texas Southwestern Medical Center in Dallas, Texas and a Hematology/Oncology fellowship at Duke University. After his fellowship in Hematology/Oncology, he worked in the laboratory of Dr. Phil Febbo in the IGSP where he used genomic strategies to study the biology and mechanism of metastatic adenocarcinoma and in particular colorectal cancer. His research now focuses on developing genomic strategies to improve prognosis and treatment of colorectal and other gastrointestinal malignancies.
Colorectal cancer is the third most common cancer in the world with approximately 150,000 new cases in the United States each year. At initial diagnosis, 25% of patients will have advanced or metastatic disease. Currently the use of chemotherapy in this setting can palliate symptoms and improve survival but cannot cure patients and metastatic colorectal cancer still remains a debilitative and incurable disease and new therapeutic approaches are required to improve our treatment of this disease. Dr. Hsu's research focuses on the application of high-throughput technologies including microarrays to match the individual patient with the most optimal therapy to improve clinical outcomes in patients with metastatic colorectal cancer.
Active efforts in the laboratory and clinic include:
Kim MK, Osada T, Barry WT, Yang XY, Freedman JA, Tsamis KA, Datto M, Clary BM, Clay T, Morse MA, Febbo PG, Lyerly HK, Hsu DS, Mol Cancer Ther. 2012 Feb 16;. Abstract
Freedman JA, Augustine CK, Selim AM, Holshausen KC, Wei Z, Tsamis KA, Hsu DS, Dressman HK, Barry WT, Tyler DS, Nevins JR, BMC Med Genomics. 2011;4:58. Abstract
Hsu DS, Kim MK, Balakumaran BS, Acharya CR, Anders CK, Clay T, Lyerly HK, Drake CG, Morse MA, Febbo PG, Cancer Invest. 2010 Aug;28(7):765-73. Abstract
Balakumaran BS, Porrello A, Hsu DS, Glover W, Foye A, Leung JY, Sullivan BA, Hahn WC, Loda M, Febbo PG, Cancer Res. 2009 Oct 1;69(19):7803-10. Abstract
Hsu DS, Acharya CR, Balakumaran BS, Riedel RF, Kim MK, Stevenson M, Tuchman S, Mukherjee S, Barry W, Dressman HK, Nevins JR, Powers S, Mu D, Potti A, Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5312-7. Abstract
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