Going DEEP in the Genome
Duke has a growing number of researchers looking into how genes are played differently from one organism to the next, based not on the spelling of their genes, but on cues their ...
Genome Biology
While the complete sequencing of the human genome was a landmark event, it was also – at least in retrospect – the easy part. Now comes the task of sorting out exactly what all those three billion base pairs of DNA actually do. In fact, just two percent of the genome is made up of protein-coding genes, and scientists are increasingly realizing that the other 98 percent can't simply be discarded as junk, as many once thought it could.
In search of meaning in the unexplained bulk of the DNA sequence, IGSP Investigators are exploring structural, functional and regulatory elements in the human and other genomes, including elements that follow known "rules" and those that may be encoded in ways scientists don't yet really understand.
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Curated Collection of Yeast Transcription Factor DNA Binding Specificity Data Reveals Novel Structural and Gene Regulatory Insights
In Genome Biology, Raluca Gordân and colleagues analyze in vitro and in vivo transcription factor-DNA binding data reported in previous large-scale studies to generate a ...
A Genome-Wide Analysis of Open Chromatin in Human Tracheal Epithelial Cells Reveals Novel Candidate Regulatory Elements for Lung Function
Greg Crawford is a collaborator on a study in the journal Thorax using DNase I hypersensitivity mapping followed by deep sequencing to generate a map of open chromatin in ...
Reduced Selective Constraint in Endosymbionts: Elevation in Radical Amino Acid Replacements Occurs Genome-Wide
In this PLoS One report, Jennifer Wernegreen tests the hypothesis that purifying selection against radical amino acid changes is less effective in two insect endosymbiont ...
