Obama bill to overhaul patent system
Some Duke researchers expressed excitement surrounding the recently approved overhaul of the U.S. patent system. President Barack Obama signed Sept. 16 the America Invents Act into ...
Systems Biology
In the old days of molecular biology, scientists tended to focus in on genes one at a time. Those genes were assembled into linear pathways, each of which took several years of work to put together. Then genomics came along and changed everything. Suddenly, labs could generate not just linear paths, but complete parts lists. Systems biology was the natural next step and, in systems biology, the network is king.
This global approach to biology requires close collaborations between experimentalists and theorists – those who are generating enormous genomic datasets in the laboratory and those with the quantitative skills to distill that complexity down and devise ways to represent it meaningfully – within a broader culture of science that is supportive of such interdisciplinary exchange.
The growth of systems biology at Duke has been driven by the creation of the NIH-funded Duke Center for Systems Biology (CSB) in 2007. The CSB was established to characterize and understand the dynamics of biological networks, including both the dynamics of network states and network structures.
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Related Publications
Cell Identity Regulators Link Development and Stress Responses in the Arabidopsis Root
In Developmental Cell, Philip Benfey and Anjali Iyer-Pascuzzi reveal surprising linkages between stress and development at cellular resolution, and show the power of multiple ...
Computation of Steady-State Probability Distributions in Stochastic Models of Cellular Networks
In PLoS Computational Biology, Mark Hallen, Lingchong You and colleagues present new methods to facilitate the study of cellular variability as a whole.
High-resolution experimental and computational profiling of tissue-specific known and novel miRNAs in Arabidopsis
In Genome Research, Uwe Ohler and Philip Benfey present small RNA datasets comprising over 200 million aligned Illumina sequence reads covering all major cell types of the ...
Network Calisthenics: Control of E2F Dynamics in Cell Cycle Entry
In Cell Cycle, Lingchong You and colleagues discuss how network modules contribute to 'shaping' E2F dynamics in the context of mammalian cell cycle entry.
Taking a Developmental Perspective on Systems Biology
In Developmental Cell, Philip Benfey says that developmental biologists' understanding of how different cells contribute to organ function and how cellular components work ...
